If you're lucky enough to have more than one laptop available, one setup that works well is to use the first laptop to send Kyma's audio to the meeting and a second laptop to run Kyma, the camera and the microphone for you to do your presentation.
For example, I connect a MOTU UltraLite to the Pacarana FW and then connect the MOTU audio output to a Focusrite Scarlett 2i audio input. Then I connect the Scarlett via USB to the audio-only laptop. An alternative way to get audio from the Pacarana to the laptop would be to use a Dante AVIO USB-to-Ethernet adapter and the Dante Via software on the audio-only laptop.
During the meeting, I can share my screen to show Kyma and present the lecture and people can hear the audio coming from the Pacarana logged in as a phantom guest in the same meeting. (You can monitor the output through local speakers set to a low level to minimize feedback).
In Zoom, you and the host of the meeting can also set some things up in advance to improve the audio quality and ensure that it is in stereo high audio fidelity mode. CDM had some good advice and instructions here: https://cdm.link/2020/09/zoom-high-fidelity-audio-mode/
I know a lot of people have been using Zoom for teaching remote music courses last semester, and I hope some of them will chime in here with their advice and experiences. Thanks!